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Posted by / 07-Apr-2020 17:43

Antihistamines make your sleepy by antagonizing central histimine-1 (H-1) receptors in the brain.The ones you see in over-the-counter sleep aids are usually diphenhydramine and hydroxyzine.Diphenhydramine (Benadryl) is the most common first-generation antihistamine found in OTC sleep aids, whether used alone or in combination with pain relievers, including acetaminophen (eg, Tylenol PM), ibuprofen (eg, Advil PM), and aspirin.Other sleep aids often contain the antihistamine doxylamine (eg, Unisom).First-generation antihistamines are widely available without a prescription and commonly used to treat allergic symptoms, including rhinitis, conjunctivitis, pruritus, eczema, urticaria, and anaphylactic reactions.These sedating antihistamines often are used alone or in combination with other ingredients in cold and cough medications, and over-the-counter (OTC) sleep aid products.It is sometimes used along with Vitamin B6 to stop morning sickness during pregnancy.Doxylamine is one of the most powerful OTC sedatives in the U. Many patients taking doxylamine encounter dry mouth, nausea, and drowsiness.

Once released, the histamine can react with local or widespread tissues through histamine receptors.For example, when you're fighting a cold (the rhinovirus), histamines widen the blood vessels in your nasal cavity, causing nasal congestion.Additionally, the increased fluid leakage from your blood vessels, combined with an increased mucous production — also caused by histamines — can result in a runny nose.They also make blood vessels more permeable, allowing proteins and white blood cells to seep into the damaged or infected tissue.But there are side effects to this healing process.

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When you get injured or your immune system detects a potentially dangerous foreign substance, certain white blood cells and tissue cells release histamines that seek out and attach to other cells that have a histamine receptor.